Genome Mapping and Genomics in Human and Non-Human Primates: 5 (Genome Mapping and Genomics in Animals) - Hardcover

This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes, and obesity), anatomic characteristics (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior) are presented.

Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure, and a discussion of the Human Genome Project. Further included are discussions of the use of statistical genetic and genetic epidemiologic techniques to decipher the genetic architecture of normal and disease-related complex phenotypes using data from both humans and non-human primates.

This book provides an introduction to the latest gene mapping techniques. It especially highlights the advances made in large-scale genomic sequencing, thanks to which we can now explain complex phenotypes such as multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes and obesity), anatomic characteristics (e.g., the craniofacial complex) and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior). Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure and a discussion of the Human Genome Project. Further aspects include statistical genetics and genetic epidemiologic techniques using data from human and non-human primates, with the aim being to decipher the genetic architecture of normal and disease-related complex phenotypes. Examples of successful applications of genomic methods to traits of particular interest in biomedical research and evolutionary biology round out the volume.